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21 This finding was replicated in the rat models of adjuvant and collagen-induced arthritis.
Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22] and antigen-induced arthritis [ 23] induces amelioration of the arthritis.
Several azaspiranes have been found to be beneficial in animal models of adjuvant induced arthritis (Bradbeer et al, 1996), autoimmune encephalitis (Badger et al, 1989), lupus erythematosus (Albrightson-Winslow et al, 1990), autoimmune diabetes mellitus (Rabinovitch et al, 1993), and solid organ transplantation graft rejection (Badger et al, 1991; Fan et al, 1993).
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In animal models of adjuvant- and collagen-induced arthritis, sinomenine improved symptoms and decreased tumor necrosis factor-α and IL-1β expressions.
In this work, 90Y PET/CT has been used as a guide for simulated modeling of adjuvant RFA.
In this study, data information of 2,789,675 patients in three hospitals in China are collected, compiled, and used as the research basis; these data are obtained through image acquisition and diagnostic parameter machine decision-making method on the basis of the machine diagnosis and medical system design model of adjuvant therapy.
One of them is the model of adjuvant arthritis induced by heat-inactivated Mycobacterium butyricum in Freund's adjuvant [ 13].
In the animal model of adjuvant arthritis, CCL2 and CCL3, up-regulated by TNF and IL-1β, are shown to contribute to the pathogenesis of inflammatory arthritis [ 37].
In the animal model of adjuvant arthritis, lower pyridoxal 5'-phosphate levels in liver implied that it was largely hepatic pyridoxal 5'-phosphate that was used during inflammation.
In a novel transgenic mouse model of adjuvant arthritis, a pure T-cell model, mice deficient in the IL-1R antagonist displayed uncontrolled IL-1 activity and developed spontaneous T-cell-dependent autoimmune arthritis [ 12].
In a rat experimental model of adjuvant arthritis, licofelone given at doses ranging between 20 mg/kg and 80 mg/kg for 26 days significantly reduced erythema and oedema, as well as arthritis-associated splenomegaly (Gay et al 2001).
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