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Advances in bioinformatics and protein modeling algorithms, in addition to the enormous increase in experimental protein structure information, have aided in the generation of databases that comprise homology models of a significant portion of known genomic protein sequences.
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Intel's modeling of a significant portion of its research-which might eventually total more than $100 million per year-after a government agency appears unique in business, says Harvard Business School's Henry Chesbrough, an expert on industrial R&D.
152d The crystallization of an HHV protease monomer for the first time further supported this model of a significant structural change between monomer and dimer and loss of the oxyanion hole as a mechanism by which dimerization regulates activity.
Missing data precluded calculation of the oxygen index and, therefore, of the model for a significant number of patients.
Conversely, for the SNP rs7981045, assuming a dominant model of inheritance, a significant association was observed when the analysis was adjusted for age and sex (P=0.042) or age, sex, and APOE genotypes (P=0.038).
For a wide class of models, a significant discovery was that efficient simulations can be found.
The adequacy of the models and a significant contribution of parameters were determined by analysis of variance (ANOVA).
Based on Hosmer-Lemeshow goodness-of-fit tests, none of the fitted models showed a significant lack of model fit.
This presentation of porcine models shows a significant variability of the experimental settings.
Comparison of these models showed a significant repositioning of residue 65 in Q151Mc/K70Q (Fig. 5), and to a lesser extent in K70Q or Q151Mc RTs (not shown).
None of the models showed a significant deterioration of the fit, implying that social homogamy is a likely mechanism of spouse resemblance for loneliness.
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