In vertebrate model organisms, numerous studies have been conducted in the mouse, but in the common fish models - the zebrafish (Danio rerio) and the Japanese medaka (Oryzias latipes) - only few publications address Egfr function.
This route of injection was modeled after numerous studies showing that peritumoral injections of radioactive tracers quickly localize to the tumor draining lymph nodes (TDLNs), a technique that is in wide use for "sentinel node biopsies" in breast cancer surgery.
This bacterial enzyme has been the model for numerous studies aimed at deciphering the catalytic mechanism of oxalate decarboxylase.
While necrotic death has been observed in animal models for decades, numerous studies have also shown that AGs-induced apoptosis in OHC is responsible for the drug-induced hearing damage [3], [11], [12], [13].
With the increasing development of transgenic (Tg) mouse models of AD, numerous studies testing the view that altered Ca2+ homeostasis might play a role in AD have recently emerged.
In the present study, we used PC12 cells, a well-defined neurodevelopmental model (Teng and Greene 1994) that readily recapitulates key events in neuronal cell development and thus has served as a model system in numerous studies evaluating exposures to neurotoxicants.
Here we study the relationships of species in the genus Polygonia (Lepidoptera: Nymphalidae), which have been used as model taxa in numerous studies on the evolution of insect-host plant interactions [ 18- 21], phenotypic plasticity in life-history traits [ 22, 23], effects of environment on distribution [ 24] and insect physiology [ 25, 26].
Clinical significance of the findings from experimental models is indicated by numerous studies demonstrating stromal PDGF receptor expression in different human solid tumors [13].
Since EE was first shown to improve survival in the R6/2 mouse model of HD [5], numerous studies have been conducted to further investigate its effects in models of neurodegenerative disease [7], [8], [13], [14], [22].
