Why does the MNGIE TP/UP double-knockout mouse model not display the clinical signs typical of human disease?
Due to space limits, the outcome of the regression model is not displayed in the text.
The coefficients for the zero inflation part of the two part model are not displayed.
Unfortunately, mice, which are favored as lung disease models, do not display a unique RBC resonance, thus limiting the preclinical utility of (129) Xe MR. Here we overcome this limitation using a commercially available strain of transgenic mice that exclusively expresses human hemoglobin.
Unfortunately, mice, which are favored as lung disease models, do not display a unique RBC resonance, thus limiting the preclinical utility of 129Xe MR. Here we overcome this limitation using a commercially available strain of transgenic mice that exclusively expresses human hemoglobin.
The genetic models of PD, established by inducing mutations associated with familial forms of PD, are of limited value because most of the murine genetic models do not display the characteristic loss of DA neurons observed in PD, as they are still at an early stage of this disease.
In accord with their longer latency, the great majority of tumors arising in our mouse models did not display any of the cardinal features of PABC, including aggressive growth rate, high Ki67, and stromal involvement (data not shown) (Schedin, 2006).
In cases where the developed PBPK model does not display appropriate agreement with adult PK data, subsequent development of pediatric models is cautioned as misconceptions depicted within the adult model are likely to be mirrored in pediatrics.
At crustal depths, anisotropy is almost constant in the models: the fast direction of anisotropy is close to being parallel to the orientation of the RRSZ (NW/SE) in the SW, whereas the NE of the model does not display significant anisotropy.
The DW and LM statistics indicated that the model did not display serial autocorrelation (DW = 1.71, LM = 0.85).
