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One of the reasons is the lack of reliable animal models mimicking severe hypertriglyceridemia and hypercholesterolemia of human T1DM to assist in the understanding of the earlier incidence of diabetic nephropathy.
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To design the human disease model mimicking severe immunodeficiency, we generated Rag2-R229Q knock-in mice without an epitope tag.
Here we introduce an animal model mimicking severe forms of Charcot Marie Tooth disease caused by GDAP1 mutations.
Here, we were interested in mimicking severe and non-self-remitting disease, as it better represents human disease; therefore, we used the chronic G6PI model.
This model is less expensive than endotoxin infusion in large animals, and it induces a more severe hemodynamic compromise with a low early mortality rate, mimicking severe sepsis after bacteremia.
This resulted in a very robust GD phenotype, mimicking severe type 2 patients (Sidransky et al., 1992).
During her second pregnancy she is helped by the understanding that for some women pregnancy and/or the postpartum period can produce hormonal imbalances which mimic severe depression.
But high doses of rapamycin can mimic severe CR without actual nutrient deficiency, thus lacking harmful effects of starvation.
This model mimics the morbidity and mortality of immunocompromised hosts such as patients with leukemia, severe burn wounds or recipients of organ transplants [8].
One model mimicked intermittent exposures and the other mimicked more chronic exposures.
The model mimicked normal, restrictive, and obstructive respiratory patterns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com