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Interestingly, these mouse models mimicked the natural progression of del 5q) MDS with approximately a third of mice developing BM failure or AML.
Almost all of the drugs tested would have been initially validated in mouse subcutaneous xenograft models, and if these combined trials were viewed as an experiment to ask whether these models mimicked the response in humans then, with 96.2 % of humans failing to respond as in the mouse models, the conclusion would clearly be negative.
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By directly comparing the relative expression ratio of orthologous genes between human and mouse, we assessed how closely the mouse models mimic the gene expression activity of two human HCC subclasses.
While these models mimic the computations behind mental state reasoning, their implementations rely on biologically implausible architectures and have a high computational overhead due to the sampling-based approach to inference.
Together with his coworkers in Magdeburg and Graz, he is constantly engaged in the development of novel models mimicking the human situation in order to establish prognostic and predictive biomarkers and to generate novel therapies.
Pre-clinical bone cancer pain models mimicking the human condition are required to respond to clinical realities.
At the other end of the complexity spectrum are physical models mimicking the biological mechanisms at play, including promoter recognition, mRNA transcription and protein translation.
Such models mimic the polar forms of the human disease and are correlated with an elevated production of IgG1 and IgG2b antibodies [24].
Therefore, the models mimic the symptomology and management profile of the disease.
To effectively unravel underlying mechanisms, experimental animal models mimicking the ICU intervention are needed.
On the other hand, animal models mimicking the dysregulated IOP in humans with glaucoma are rare.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com