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From the perspective of our results, adding geology, elevation, and landforms to the models might allow for more realistic results and in many cases narrower predictions of suitable habitat.
Simulations of these phenomena in computational models might allow further reconciliation of the results of these types of studies.
Better predictive models might allow appropriate targeting of cumbersome or costly preventative interventions and enhance the power of clinical studies examining such interventions.
Using the HSVtk-GCV system described here, we are in the process of testing the idea that 3MR transgenic mouse models might allow tracking and eliminating senescent cells in vivo.
These models might allow us to identify the earliest events of AD, to investigate aspects of AD pathogenesis that are not recapitulated in animal models, and to validate and build upon findings from GWAS.
Such models might allow recapitulation of severe ALI, as well as experimental manipulation and temporal analysis of distal lung tissue, which are not achievable using in vivo human models.
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The model might allow the study of the pathophysiology of autoimmune hepatitis and viral hepatitis.
Such a model might allow Nup153 to uncoat the viral core in the region associated with the central pore of the NPC.
Importantly, our model might allow to possibly unlock fundamental mechanisms of regeneration that could be used in the future to also repair adult hearts.
Therefore the model might allow further studies clarifying these crucial steps of angiogenesis and tumor invasion and metastasis which are promising targets for new drugs against solid tumors [ 52, 53].
Thus, the high tumor incidence (100%) and convenience of chemical treatment in this inducible model might allow it to be used for detailed analyses of liver tumor progression and/or regression as well as for potential anti-cancer drug screens.
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