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On the other hand, models using bins that are too wide (e.g., > 14 ppm in the chemical shifts plane XY) may assign fingerprint elements encoding divergent structural features to the same bin, thus producing models lacking in their ability to decode the underlying relationship between structure and activity.
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However, these models lack in-depth experimental validation, in part because void coalescence is difficult to capture experimentally.
Previous FE models lacked in precise ligament geometries and material properties, which might have influence on the results.
What the model lacks in space, it makes up for in its unique dynamics and finesse.
Conditional models lacking Fxn primarily in the pancreas (Ins2-Cre; Table 1) were generated to model the pathophysiology of diabetes mellitus associated with FRDA (Ristow et al., 2003) (Table 1).
Overall, these results support the involvement of neuronal damage to the pathology of DR in experimental models lacking CX3CR1.
We therefore used two different conditional mouse models lacking Prkg1 in the nervous system.
To characterize the influence of PRKG1 on sleep and circadian rhythmicity in mammals, we analyzed two different mouse models lacking functional PRKG1 in the brain.
Toxicity studies in models lacking the above proteins would overestimate retinaldehyde toxicity.
Their abundance is matched by in silico models lacking real functionality and are thus a by-product of the network building rules.
Further tests in mouse models lacking the specific epithelial receptor will permit more targeted examination of the complex interplays between the pathogen and the lung epithelium.
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