However, these models lack in-depth experimental validation, in part because void coalescence is difficult to capture experimentally.
Previous FE models lacked in precise ligament geometries and material properties, which might have influence on the results.
On the other hand, models using bins that are too wide (e.g., > 14 ppm in the chemical shifts plane XY) may assign fingerprint elements encoding divergent structural features to the same bin, thus producing models lacking in their ability to decode the underlying relationship between structure and activity.
Referee Comment: "Further comments: "Moreover the SDLCs famous for the quick development (Rapid Prototype Model, Agile Development Model, Extreme Programming Model, Evolutionary Model, Code and Fix Model), lack in quality software production": This is a rather controversial statement, as the list includes some generally respected models.
Further comments: "Moreover the SDLCs famous for the quick development (Rapid Prototype Model, Agile Development Model, Extreme Programming Model, Evolutionary Model, Code and Fix Model), lack in quality software production ": This is a rather controversial statement, as the list includes some generally respected models.
When analyzing Rasch models, lack of dimensionality is reflected in poor fit indices.
In vitro models lack cellular heterogeneity whereas in vivo models do not fully reflect human pathology.
However, such models lack biological realism in the case of SRDs since, to the authors' knowledge, there are no documented cases of sexual transmission or paternal inheritance in feminising or male-killing parasites.
Nevertheless, the above in-vitro models lack the biological complexity of vascular system in vertebrate animals.
Conditional models lacking Fxn primarily in the pancreas (Ins2-Cre; Table 1) were generated to model the pathophysiology of diabetes mellitus associated with FRDA (Ristow et al., 2003) (Table 1).
9 Furthermore, transgenic mouse models lacking AMPKα2 activity in muscle show complete inhibition of AS160 phosphorylation and glucose transport on stimulation with the AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside.
