As opposed to a linear evolutionary model, it is conceivable that there were several overlapping collections of sayings attributed to Laozi from the start, each inhabiting a particular interpretive context, from which different versions of the Laozi were derived.
Because CD4+CD25+Foxp3+ T regs are capable of inhibiting proinflammatory responses by releasing IL-10 and TGF-β1, in our model and in other autoimmune models [10], it is conceivable that these CD4+CD25+Foxp3+ T regs might play a central role in regulating the autoimmune response during Plasmodium infection.
Based on these reports and on the proximity of C286 to its active site revealed by the 3D model of AgAChE, it is conceivable that a chemically stable molecule can be made to react with C286 and irreversibly inhibit AgAChE upon binding to the active site (Figure 6).
Infiltration of monocytes into the optic nerve has been reported in some animal models [ 22] and it is conceivable that glaucomatous RGC loss induced by elevated IOP initiates a systemic immune response.
As the model proposed by Nekouzadeh and colleagues [36] does a good job at fitting the single step data (although admittedly with a lot of parameters, 35 in our case), and to a lesser extent so does the original QLV model (with 8 parameters), it is conceivable that one could build on it by manipulating its output to also fit the double step data.
Since the use of Ang-1 offers clinical benefits as a quiescence agent for endothelial cells in an elegant model of sepsis, 76 it is conceivable that restoring the Ang-2/Ang-1 balance in favor of Ang-1 would block and potentially reverse the ongoing inflammatory processes in CM patients at the time of admission.
However, beside the relevance of metformin doses in experimental model and clinical settings, it is conceivable that translational studies should evaluate metformin at conventional antidiabetic doses but also investigate more aggressive dosing to recognize distinct mechanisms of action relevant for antineoplastic activity.
It is conceivable that these models may not mutual exclusive.
It is conceivable that the model has implications and applications for health care providers beyond the realm of cancer.
It is conceivable that similar chart models obtained from large sample sizes could replace the CMC for OLT in patients with HCC.
