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Moving forward and testing the hypothesis of haploinsufficiency as a disease mechanism is difficult, and using mouse models is problematic.
The use of importance sampling in such graphical models is problematic because it generates many useless zero weight samples which are rejected yielding an inefficient sampling process.
Care goal transition to comfort models is problematic and often delayed.
Tracking down links with conventional animal models is problematic because scientists believe some important classes of neurons exist only in primates, he points out.
Furthermore, given that we must assume that it has not yet achieved environmental equilibrium, using methods that rely on (pseudo) absence data, such as generalized linear models or generalized additive models, is problematic (Guisan and Thuiller 2005).
It can certainly be argued that the choice of 16-state models is problematic because it is difficult to fit these models to real data due to their parameter richness and heavy computational costs.
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He has a tendency to dither and he took too long to recognize that Citigroup's financial supermarket model was problematic.
From the mechanistic perspective, each of these features of the Nagel model is problematic.
Attribution of geotechnical and geochemical properties to the 3D model is problematic without intrusive investigations and sampling.
They also say the company's basic business model is problematic, since it relies on men and women being incarcerated in large numbers.
Li Zhuang, a lawyer who was imprisoned as part of the "Striking Black" policy, said that "the Chongqing model is problematic because the city's leaders do not follow the rule of law".
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