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The message is that: "The evaluation of environmental models is non-trivial and is dependent on the context and purpose of the model".
The mathematical analysis of these models is non-trivial.
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Having known that loop modeling is non-trivial and is most accurate when the equivalent regions are obtained from homologues, we have explored the use of information on local conformation through representation of templates as Protein Blocks in obtaining clues on comparative modeling.
While the construction of the time-varying internal model unit is non-trivial by itself and a very recent research outcome enables its synthesis for a class of linear time-varying systems, the effective stabilization of the augmented system (internal model unit and plant) for practical applications remains a challenge.
As is the case in standard PCA, model selection is non-trivial because a higher fit percentage can always be achieved by selecting more components.
We agree it is important to address the potential non-specific effect of RA experiments, for example on general growth and development of the bud (even in this non-model system which is non-trivial to work with).
Thus, modeling functional signal changes is non-trivial and exploratory data analysis (EDA) may be rather useful.
Generally, the incorporation of these geometrical constraints into a theoretical model for chromosome configurations is non-trivial.
To perform model selection on unlabeled data is non-trivial because it is difficult to evaluate the models.
However, most appliances are subject to physical constraints, for example, washing machine being non-interruptible, and consequently, the modeling of the decision space is non-trivial.
We could expect better performance if we prepare models trained with single reverberation conditions and choose a best-matched model at the run time in some way, although the choice of the best-matched model at run time itself is non-trivial.
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