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The forward problem using the regional models is computed on the nodes of an equal area grid (also at the median altitude of the measurements, 460 km).
An additional analytical solution that simulates the behavior of laminates under the plane stress hypothesis – shared by all the considered models – is computed.
The test for positive selection was conducted using a likelihood-based method, where the likelihood of different evolutionary models is computed given a gene sequence alignment and a reconstruction of the phylogenetic history of the genes.
Currently the gold standard for the generation of 3D models is computed tomography [ 22].
The derivative for the proportion of covarion sites parameter π in the general and Galtier models is computed analytically as the difference of the covarion likelihood and RAS likelihood across the sites.
The Q-score between a pair of residues (i, j) in the two models is computed as: Q ij = exp[ − (r ij a − r ij b )], where r ij a and r ij b are the distance between Cα atoms at residue positions i and j in models a and b, respectively.
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The different models were computed with Modeller version 9.8 [ 32].
Two source models are computed.
The expected number of transmissions for both the models were computed.
Another set of field models are computed by individual dedicated chains.
Models were computed using a sliding window which included 3 years of CHAMP data.
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