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In transgenic mouse models, induction of ER stress in the alveolar epithelium predisposes to enhanced lung fibrosis after treatment with bleomycin [26].
The analysis of DNA content revealed that in both cellular models induction of BCL11B caused slight but significant accumulation of cells at G1 phase of cell cycle.
In both models, induction of PTEN recombination led to the development of prostatic neoplasias and myeloproliferative disorders, respectively.
Among the various animal models, induction of diabetes through diet provides more resemblance to human type-2 diabetes.
In experimental models, induction of collagen-specific responsiveness results in a disease similar to RA [ 15, 16].
In multiple cellular models, induction of c-Myc expression correlated with induction of the mir-17 cluster.
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In the murine model, induction of Th1/Th17 cells by CX3CR1+ DCs initiates the host defence against intestinal pathogens, such as Salmonella [40].
As demonstrated in the conceptual molecular model, induction of cellular acidification through differential expression of H+ transport genes appears to be one of the key physiological modifications made by P. temperata to persist in the enduring infective juveniles.
In the direct activation model, induction of Bim or Bid is required for Bax or Bak to oligomerize and form pores in the outer mitochondrial membrane (MOM) [9], [10].
In a mouse model, induction of HER2/neu led to mammary gland tumor development.
Moreover, in our model, induction of PTEN excision is performed adult mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com