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The significance of quadratic model of each response was determined by analysis of variance, where all models indicated sufficient significance with p-value < 0.0001.
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Checks of model adequacy indicated sufficient fit (Supplemental Figures S1 and S2).
A value of ≥0.70 indicated sufficient internal consistency.
Values equal to or greater than 9.5 indicated sufficient quality.
A test-retest study indicated sufficient reliability [ 18].
The ESS performance criteria (> 1000) indicated sufficient posterior parameter sampling.
It is unclear whether the paraplegin defects in these patients would have directly caused the elevated OPA1 levels, as previous work in animal models indicated that abnormal paraplegin is not sufficient to alter OPA1 metabolism (Duvezin-Caubet et al., 2007; Ehses et al., 2009).
For the RMSEA values <.08 indicate an acceptable model fit and for the χ/ df statistic values between 2 and 4 indicate sufficient model fit.
Comparisons between the Weibull and exponential models demonstrated the Weibull model as the better fit, indicating sufficient evidence to reject the null that the hazard is constant over time.
The intraclass correlation coefficient indicated that 38% of the variance was due to within-hospital effects, indicating sufficient variance for using a random intercept model.
All F-statistics from the first-stage regressions in the instrumental variable models were greater than 10 (17.4 for contemporaneous and 16.8 for previous serum CRP) indicating sufficient strength to ensure the validity of instrumental variable methods in these data.
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