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Coupling free energy in the absence and presence of changes elsewhere in the molecule is discussed in terms of specific folding models, including stepwise folding and concerted changes.
The full models, including stepwise covariate elimination steps and model optimisation transformation, are provided in the Additional files.
The full models including stepwise covariate elimination steps and model optimization transformation can be found in the supplementary files.
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B ottleneck tests for excess heterozygosity using several mutation models including the stepwise mutation model (SMM), infinite allele model (IAM), and a two phase model (TPM).
We used stepwise models including increasing number of variables.
Candidate variables with a p-value ≤0.1 within bivariate tests (analysis of variance, chi-squared, correlation) and variables that were clinically important were tested for inclusion within a series of statistical models including forward, backward, and stepwise selection models.
For this purpose, stepwise logistic regression models including sociodemographic and household variables were performed.
From reviewing the statistical methods of the manuscript, we hypothesize that the reported confidence intervals are too narrow because the analysis included stepwise model selection, which was not replicated during the bootstrap procedure.
When the two additional covariates were included stepwise in a multivariate model, both remained significant.
Initial models included all exposure variables; backwards, stepwise elimination then was used to remove all variables with p-values > 0.2.
The multivariable models include the significant variables from backwards stepwise procedure.
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