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To probe this, we investigated the effect of PHGDH depletion in several CSLC models including; primary, patient-derived BTICs, generated from surgically resected glioblastomas and characterized with the expression of CD13316, widely used breast CSLCs (BCSLCs 14, and human ECSLCs24,25.
These observations were made in multiple chondrocyte culture models, including primary and immortalized cells, and human and mouse species.
Although these findings were first observed in isolated rat hepatocytes, similar results have since been obtained in numerous cell models including primary human hepatocytes [ 13].
Previous studies have highlighted the fact that the expression of LIF can be induced by hCG in a number of models including primary cell cultures (13), human endometrial infusion (15), and, most recently, a baboon endometrial infusion model (14).
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At the physician level, the models included primary care physician age, sex, years since graduation, and Canadian graduate status.
Using the thermal hydraulic code MERSAT detailed model including primary and secondary loop was developed for the IAEA's reference research reactor MTR 10 MW.
Based on integral system analysis code of PHWR, the plant model including primary heat transfer system (PHTS), calandria, end shield system, reactor cavity and containment has been developed.
For computing the turbidity spectrum, we constructed a model including primary crystals whose distributions were parameterized by mean and standard deviation, and also including aggregates consisting of mean sized primary particles, parameterized just by mean aggregate size.
Based on recent evidence we propose a model including primary and secondary insults in glaucoma.
The first step was a partially adjusted model including primary covariates that describe fundamental demographic and socioeconomic characteristics, such as age, country of origin, occupational status, and educational status.
The developed model includes primary and secondary systems, containment, and related safety systems.
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