Sentence examples for models including murine from inspiring English sources

Overexpression of the inhibitory Smad7 protein or treatment with a small molecule inhibitor of Smad 3 reduces the fibrotic response in all of these animal models (including murine systemic lupus erythematosus) and holds out a promise for treatment of pathological fibrotic human diseases [ 60, 61].

Preclinical models demonstrate that p38 inhibitors are effective in a number of animal models of arthritis, including murine collagen-induced arthritis.

RyR2S/S atria showed reduced INa compared to WT. Increased AF susceptibility in association with conduction abnormalities has also been observed in other models of altered Ca2+ homeostasis, including murine CREM-IbΔC-X AF (Li et al. 2014) and CSQ2−/− hearts (Glukhov et al. 2013).

Therefore, results from animal models, including the popular murine ones, are not always translatable to humans and conclusions should be made with caution.

In experimental models, including in vivo murine myocardial IRI or the isolated Langendorff-perfused rat heart, as well as in cardiomyocytes subjected to hypoxia, eRNA promoted TNF-α liberation through the activation of TNF-α converting enzyme (TACE) [ 10].

For RIC, in which cycles of brief ischemia and reperfusion applied to the upper or lower limb protect the myocardium from lethal IRI, there exist extensive preclinical data in a range of animal models including in vivo murine, rat, rabbit and porcine models of MI (reviewed in [ 20, 56]).

Some of the preclinical models currently used include murine, leporine, ovine, caprine, porcine, canine, and equine models.

Zamanian-Daryoush et al.11 reported that apoA-I suppresses tumor growth and metastasis in multiple animal tumor models including the aggressive B16 F10L murine malignant melanoma model.

However, despite the obvious benefits of murine models (including experimental simplicity, small size, familiarity, ease of husbandry and relative low costs), these differences mean that these animals do not faithfully model the clinical situation in DMD: therapeutic trials can be hard to assess in mildly affected mdx mice and are difficult to interpret in double-mutant mice [18].

Spontaneous genetically lupus-prone murine models including NZBWF1/J (NZB/W), MRL/MpJ-Faslpr/J (MRL-lpr), and congenic lupus strain B6.MRL-Faslpr/J (B6-lpr) have been extensively used in numerous published reports and have provided valuable insight into lupus pathogenesis.

For example, Helicobacter hepaticus, a potential pathogenic microorganism that has been reported to induce colitis, hepatitis, and hepatocellular carcinoma in numerous murine models including A/JCr, SCID/NCr and RAG-2−/− mice failed to induce colitis or to potentiate colitis in conventionalized IL-10−/− mice [24].