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Three-dimensional culture systems help to maintain this architecture and have been used for the successful culture of follicles in various animal models, including humans and nonhuman primates, and have resulted in live birth in rodent models.
The discovery led him to explore the molecular pathway of the DNA damage response in other complex models, including humans.
Food, temperature and physical activity, the primary environmental factors, affect healthspan in most animal models, including humans.
Dopamine (DA) and serotonin (5HT) have been implicated in the regulation of aggression in a wide variety of animal models including humans [4] [8].
Air pollution produces oxidative stress and inflammation in many experimental models, including humans.
However, except for mouse models, their characterization and their origins have remained controversies in other models including humans.
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What is important to note is whether these models are able to shed light on specific questions in a way that alternative models, including human intuition, does not.
This is of particular interest since Fyn has been implicated in AD pathogenesis across various models, including human subjects [ 23].
Reduced aortic NO bioavailability has also been reported in various animal models, including human CRP-overexpressing transgenic (hCRPtg) mice (21).
Antitumour activity was noted in several tumour models including human ovarian carcinoma xenografts with acquired resistance to cisplatin (CH1cisR) and carboplatin (HX110P).
Additional studies also need to be conducted on the mechanism of action, long term toxicity, and efficacy on other experimental models including human and standardization before it can be recommended for human use.
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