Stable or transient transfection of EBNA-1 was shown to affect the expression of a range of cellular genes in NPC and HD models, including genes involved in transcription, translation and cell signaling [14], [15].
The co-evolution models, including "gene-for-gene", "matching allele", and "matching genotype", have already been proposed [ 15- 18].
It is hypothesized that complex diseases are due to a myriad of factors including environmental exposures and complex genetic risk models, including gene-gene interactions.
3. A parity-specific model including gene x parity interaction and the random permanent environmental effect.
Ideally, one could fit a model including gene, muscle type, gender, age and their interactions and decide if there is significant effect for any of these factors.
Therefore, the reproducibility of cancer survival model including gene expression data across different centers or studies could be still controversial, that could be caused by the geographic and/or methodologic variations, and it should be extensively studied.
The 14 commonly altered genes by all PPAR agonists in both cell models included genes implicated in lipid metabolism (CD36, PLIN4, ADFP, ANGPTL4) and oxidative stress (POR, HMOX1).
Previous quantitative transformation models included genes such as those encoding simian virus 40 T antigen and p53DD to inactivate p53 [ 3, 4].
This work seeks further insights into the design of Boolean network models through the construction and analysis of a class of models that include more concrete biochemical mechanisms than the usual abstract model, including genes and gene products, dimerization, cis-binding sites, promoters and repressors.
