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The quantity and diversity of conceptual models in translational science may complicate rather than advance the use of theory.
Of course, the relevance of animal models in translational research may always be questioned.
Therefore, cautions should be exercised when interpreting data from animal models in translational research that aims at human application.
Here, we discuss the pros and cons of using both of these models in translational breast cancer research.
These results mirror recent clinical findings and again emphasize the utility of LTED models in translational research.
The 3-day meeting, 'Zebrafish Models in Translational Medicine', which was co-sponsored by Disease Models & Mechanisms (DMM), was held in a small town in the outskirts of Paris (Gif-sur-Yvette).
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The olfactory neural epithelium, easily accessible in clinical settings, is a promising surrogate model in translational brain medicine, complementing the limitations in current engineered cell models.
Established by a generous donation from the Swiss entrepreneur and philanthropist Hansjörg Wyss, the Wyss Center presents a new model in translational neurotechnology research, offering competitively awarded support for projects that have the potential to make substantial clinical impact.
Ongoing collection and integration of human PPIs from different sources, both experimentally and computationally, can enable disease-specific network biology modelling in translational bioinformatics studies.
The cloning of the guinea pig survivin gene now allows to employ this animal model in translational hearing research to further dissect the molecular details and to target this cytoprotective resistor.
Last but not least, the zebrafish has recently emerged as an increasingly prominent model in translational research and drug discovery [see our popular poster article by Jennifer B. Phillips and Monte Westerfield (Phillips and Westerfield, 2014)].
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