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Creation of more physiologically relevant cell models in tissue culture is a requisite for advancing medical research.
For example, the traditional 2D in vitro wound healing models in tissue culture plates not only lack complete differentiation of the cultured epithelium [58], but also induce TGF-β1 synthesis due to the absence of any BM [23].
For more general detail on mathematical models in tissue engineering, we refer to the recent review by O'Dea et al. (2013a).
Limited distribution of several chemotherapeutic agents has been shown in multi-cellular models in tissue culture and in experimental and human tumours and is a probable cause of clinical drug resistance [ 1- 8].
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Cellularized collagen gels are a common model in tissue engineering, but the relationship between the microstructure and bulk mechanical properties is only partially understood.
We adapted our cell model to reproduce heart failure conditions and embedded this model in tissue simulations.
Their multi-lineage differentiation capabilities herald a probable application model in tissue engineering and induced pluripotent stem cells.
The Arterovenous Loop (AV Loop) model is a vascularization model in tissue engineering research, which is capable of generating a three dimensional in vivo unit with cells as well as the supporting vessels within an isolation chmaber.
These cells are used as model cells in tissue engineering [41, 42].
Here we characterized Ntsr1 mRNA and protein expression in the murine KitK641E GIST model and in tissue microarrays of human GIST.
Second, P4 reduces the proliferation rate in normal OSE cells both in a primate model and in tissue culture [ 6- 8] and suppresses the transformed phenotype in vitro [ 9].
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