Sentence examples for models in immunodeficient from inspiring English sources

Recently, a prominent role of FAK in promoting mammary tumorigenesis, progression and metastasis has been unveiled by different animal models of human breast cancer, including xenograft models in immunodeficient rodents and spontaneous tumor models in transgenic mice that have specific deletion of FAK in the mammary epithelial cells during embryonic or postnatal development.

To evaluate whether hESC-ECs are capable of forming functional blood vessels in vivo, we used Matrigel plug and tissue-engineered vessel models in immunodeficient SCID mice that allow dynamic and long-term observation of blood vessels derived from implanted cells [8], [17].

So far, two main strategies have been explored to create humanized CML models in immunodeficient mice.

Both groups used xenograft models in immunodeficient animals with all the potential problems regarding the microenvironment interaction mentioned above.

Even more complicated is the situation when haematological malignancies as models in immunodeficient mice are used (Uckun, 1996).

Human tumour xenograft models in immunodeficient mice are widely used to assess pharmacokinetics, biodistribution, and treatment efficacy because they are inexpensive and easy to replicate [ 1].

We developed a wound model in immunodeficient rodent and treated it with engineered vascularized constructs from endothelial progenitors or early vascular cells-derived from human induced pluripotent stem cells (hiPSCs) reprogrammed either from healthy donor or type-1 diabetic patient.

In this study, we demonstrated that implantation of periosteal-derived mesenchymal progenitor cells (PDMPCs) that overexpressed an N-terminal sonic hedgehog peptide (ShhN) via an adenoviral vector (Ad-ShhN) restored periosteal bone collar formation in a 4-mm segmental bone allograft model in immunodeficient mice.

We have analyzed visually the early human tumour angiogenesis with our transparent chamber model in immunodeficient mice.

In another study by Chang et al. [ 49] VEGF up-regulation following PDT was monitored in the PC-3 prostate cancer model in immunodeficient mice.

We have developed a mammary tumor model in immunodeficient mice in order to separate the stromal cells from the tumor cells, as indicated in Figure 1B.