These novel animal models, in association with in vivo imaging technologies, provide a global view of the target tissues of drug action following acute and repeated drug treatment, thus enabling the prediction of potential side-effects in the early phase of preclinical studies.
An isogenic mutant of the glycosyltransferase gacI, which is defective for GlcNAc side-chain addition, is attenuated for virulence in two infection models, in association with increased sensitivity to neutrophil killing, platelet-derived antimicrobials in serum, and the cathelicidin antimicrobial peptide LL-37.
Our study suggests that the most accurate data will be obtained from combination of both mouse models in association with multiple imaging modalities since the TH-MYCN system allows testing of the drugs in an immune proficient model while the orthotopic xenograft system uses human cells grown in the proper microenvironment.
Logistic regression was used for the different models in association analyses (sex as a covariate, stratified by sex, and stratified by either RF or anti-CCP status).
The miR-146a SNP was found to be codominant, recessive and additive models, whereas, the miR-196a2 SNP was found to be codominant, dominant, and additive models in association with pulmonary TB.
The allele and genotype frequencies of the miR-499 SNP were significantly different between the TB patients group and the healthy control group in the Uygur population, and were found to be codominant, dominant, recessive and additive models in association with pulmonary TB.
Shock wave model in association with the mass conservation and Newton׳s second law are employed to solve the problem.
This study aims to develop an expert system based on the artificial neural network (ANN) model in association with a modified firefly algorithm (MFA).
The SDCDD model (in association with the Redlich Peterson isotherm) is demonstrated to be the necessary alternative of the parallel diffusion model proposed by Yoshida.
This model, in association with the experimental data recorded on board a high-speed marine craft, is used to study seat isolation system designs.
In this paper, a novel element-free IMLS-Ritz model in association with Reddy's higher-order shear deformation theory is presented to study the impact analysis of CNTRC plates with both uniform and functionally graded carbon nanotubes (CNTs) distributions.
