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Fully exploring the regulatory architectures of aging will likely require the use of a broad range of animal systems many of which are not currently regarded as mainstream models in aging research.
No comparable composite surveying approaches are established yet for invertebrate models in aging research.
Animal models of osteoarthritis (OA) include spontaneous models in aging animals, genetically modified mice, as well as surgically, enzymatically or chemically induced models [ 7].
Although its relevance to the organismal aging remained unclear, yeast CS was one of the most fruitful models in aging research.
Many animal models have been developed to investigate the pathogenesis of osteoarthritis, such as spontaneous models in aging animals, enzymatically or chemically induced models, and surgical induced models, as well as ACL transection combined partial meniscus resection [ 14- 17].
Our findings will serve as a valuable resource in aging studies, promoting the pig as a model organism for human aging research and accelerating the development of comparative animal models in aging research.
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The fact that these mice are being preserved in repositories and made available to the scientific community represents a distinct advantage for using mouse models in ageing research.
An Escherichia coli based infection model in aging mice was also designed to validate the protective attributes of LF.
Serving as an efficient model in aging research for decades, fruit flies possess unique advantages over other organism models.
Nevertheless, the actual employment of this nonprimate model in aging study is still quite rare for the following reasons.
Chronological lifespan of yeast cells in stationary culture is the most fruitful model in aging research and dozens of papers have been published in Nature, Science, Cell and Cell Cycle.
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