Exact(1)
Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia.
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Cognitive models implicate the role of beliefs as one factor in buying behavior, for example, "this item is unique and will help me improve my life".
Studies of animal models implicate the antidiuretic hormone arginine vasopressin and its secondary messenger 3′,5′-cyclic adenosine monophosphate (cAMP) as promoters of kidney-cyst cell proliferation and luminal fluid secretion [ 5, 6].
Despite early animal models implicating the non-telomeric role of DKC1 mutations in disease, a more recent mouse model that directly disturbs telomere maintenance displays many of the features of DC, directly implicating telomerase and telomere maintenance in development of the phenotype.
Yet another model implicates the generation of an extrachromosomal circular intermediate generated by a single crossover [ 42, 43].
The mechanism underlying cortical neurogenesis demands further clarification, but the most current model implicates the mitotic spindle angle as a determinant of cell fate.
Potten, C.S. & Allen, T.D. A model implicating the Langerhans cell in keratinocyte proliferation control.
The findings are consistent with a biopsychosocial model, implicating the need to consider the impact of process and clinical variables on adjustment to chronic pain in persons with SCI.
Our findings in this model implicate the human apoE E4 allele as a susceptibility gene for AMD and support the hypothesis that common pathogenic mechanisms may underlie AMD and Alzheimer's disease.
These study limitations likewise made it impossible to ascertain, based on four adult trials[ 18, 19, 21, 22] and one pediatric RCT,[ 17] whether omega-3 fatty acids consistently and positively influence the lipid mediators of inflammation in ways congruent with the biological model implicating the lipoxygenase and cyclooxoygenase pathways in asthma.
Although the early apparent loss of podocytes in the STZ diabetic rat and mouse models implicates podocyte damage in the pathogenesis of diabetic nephropathy, it is also striking that such changes precede albuminuria and glomerulosclerosis by at least several months.
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