Early studies in animal models implicated activated factor IX or the presence of procoagulant phospholipids as potential thrombogenic determinants in PCCs [ 26, 27].
The pedunculopontine nucleus, a component of the reticular formation, is topographically organized in animal models and implicated in locomotor control.
47 In addition, the experimental cell and animal models implicate abnormalities in dopamine receptor regulation due to receptor desensitization resulting from increased GRK4 activity, then decreased DRD activity and increased AT1 receptor activity.
The recent failure of substance P receptor (NK1) antagonists in clinical trials for treatment of pain spawned additional studies asking why preclinical models implicating SP in chronic pain did not translate into a viable target for analgesic development.
Neuroanatomic models implicate failures in circuits connecting the brain's cortex and subcortex, and imaging techniques implicate the basal ganglia and frontal cortex.
Human studies and animal models implicate TNFα in atherosclerotic plaque formation [7,8].
After obtaining data from two separate mouse models implicating MCs in the mechanism of DENV vasculopathy, as well as evidence that drugs that target MCs or their products can restore vascular integrity, we sought to validate this key finding in humans.
Very importantly, virtual tumor T4 satisfies concurrently a considerable number of constraints which drastically limit the value range of the critical model parameters implicated in tumor response to therapy (e.g. Psym, Psleep).
A diversity of chemokines are upregulated in the animal model and implicated in enhancing microglial mobility to localize cells in proximity to amyloid deposition.
The utilization of a highly stable, easily purified recombinant protein like human γD crystallin provides an inexpensive, resilient model protein implicated in human disease that tolerates some level of error on the part of beginner students and TAs.
