Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia.
Despite early animal models implicating the non-telomeric role of DKC1 mutations in disease, a more recent mouse model that directly disturbs telomere maintenance displays many of the features of DC, directly implicating telomerase and telomere maintenance in development of the phenotype.
The findings are consistent with a biopsychosocial model, implicating the need to consider the impact of process and clinical variables on adjustment to chronic pain in persons with SCI.
Yet another model implicates the generation of an extrachromosomal circular intermediate generated by a single crossover [ 42, 43].
The mechanism underlying cortical neurogenesis demands further clarification, but the most current model implicates the mitotic spindle angle as a determinant of cell fate.
These study limitations likewise made it impossible to ascertain, based on four adult trials[ 18, 19, 21, 22] and one pediatric RCT,[ 17] whether omega-3 fatty acids consistently and positively influence the lipid mediators of inflammation in ways congruent with the biological model implicating the lipoxygenase and cyclooxoygenase pathways in asthma.
Studies from cell culture models implicate impaired degradation through the proteasomal pathway as one cause of GFAP increase, despite a near simultaneous increase in autophagy (Tang et al., 2006, 2008).
8 Although these translational models implicate developmental abnormalities of the striatum and cortex in pathological hair-pulling, and neurobiological overlap between trichotillomania and obsessive compulsive disorder has been suggested, there have been no whole-brain studies of the disorder with which to validate these approaches.
Neuroanatomic models implicate failures in circuits connecting the brain's cortex and subcortex, and imaging techniques implicate the basal ganglia and frontal cortex.
