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Either way you slice it, there is a lot of water in the transition zone: "Both models implicate a transition zone that is at least locally water-rich," he wrote.
In addition to its role in left-right patterning, compelling evidence from recent studies using mouse models implicate a complex and critical role for the cilium in CHD pathogenesis in a much broader context (Friedland-Little et al. 2011; Li et al. 2015).
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DCLK1 expression was recently identified as an intestinal cancer stem cell-specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer.
Recently, Dclk1 expression was identified to be an intestinal cancer stem cell specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer.
Indeed, there is now evidence emerging from experimental breast cancer cell models implicating a role for erbB receptors in resistance to IGF-IR blockade, with Haluska and colleagues [ 47] showing that EGFR/erbB2 signalling can confer resistance to the IGF-IR tyrosine kinase inhibitor BMS-536924 in MCF-7 cells.
MEOX2 was originally identified as GAX (Growth Arrest Specific Homeobox), since it is upregulated during endothelial cell activation in an injury healing model, implicating a specialized and dynamic role for cell cycle regulation by this homeodomain protein in adult tissues [16].
This model implicates a novel interaction between canonical and non-canonical Wnt signalling pathways in the regulation of neuronal morphology in OB interneurons that may be important elsewhere in the nervous system.
This quantitative model implicates a possible dose response relationship between number and severity of adversities and likelihood of a depressive outcome, even if this effect is nonadditive and complex (Brewin, Andrews, & Valentine, 2000; Fergusson, Boden, & Horwood, 2008; Gilbert et al., 2009; Li, Ahmed, & Zabin, 2012; Widom, DuMont, & Czaja, 2007).
As a result, this model implicated an implicit effect on mortality.
Maoa knockout models implicate this gene as a regulator of neurochemical pathways, leading to increased levels of serotonin (5-hydroxytryptamine (5-HT)), norepinephrine, dopamine, and noradrenaline neurotransmitters in adult brain [ 23, 24].
However, there are over 240 mouse models of NTDs, and only a minority of these models implicate folic acid metabolism through mutations in folate pathway genes or have been shown to be responsive to folic acid supplementation [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com