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For immunofluorescence, models implanted with PKH26-labeled monocytes (red) were stained for anti-human CD68 (Dako, Glostrup, Denmark) followed by goat anti-mouse Alexa Fluor 488 (green).
Moreover, in both the mouse models implanted with MSCs and osteoporosis, the treatment with low doses of bortezomib resulted in an increase in the bone formation.
In addition, humanized mouse models implanted with tissue-engineered human liver (Chen et al., 2011) could potentially develop leukemia following chronic exposure to benzene.
This could account in part for the low incidence of systemic metastasis seen in xenograft models implanted with tumor cells taken from human metastases.
Tissue models implanted with CFSE-labeled monocytes (green) were air-exposed for 3 days to allow stratification of apical layers and mucus secretion.
For many years, mouse xenograft models implanted with human cancer cells lines have been used extensively for predicting responsiveness to anticancer target agents.
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To further investigate the role played by WNT10A in these morphological changes, we established another nude mouse model implanted with HeLa cells overexpressing WNT10A (Figures 3A and S3).
The angiogenesis in the CAM model implanted with CYB5R2-transfected NPC cells was inhibited.
FEMs included the intact model, unstable BI model, unstable BI model implanted with either Cage + Plate device or Cage + TARP device at C1-C2 segment.
The models implanted are coated with HA in the acetabulum and in the metaphyseal area of the stem.
Tissue models were implanted with 200,000 monocytes, cultured and harvested at D7.
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