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Efficacy testing of these drugs in xenograft models, however, does not always reflect the heterogeneity of human breast cancer - and the concept of early phase zero trials as proof of concept may be an effective way to anticipate failure and to reject ineffective drugs before larger scale clinical development is triggered.
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These models, however, do not meet the mathematical boundary condition.
Ab initio calculations on relevant models, however, did not support this result.
These models however did not give an in-depth explanation of the charging of the carriers into floating gate during dielectric deposition.
Today's businesses models, however, do not support such ongoing care, except in the rare cases where the insurer and provider are the same.
Many of these models, however, do not utilize zoning, information in their deployment because many model designers do not believe zoning to be a relevant, criterion for the prediction of urban growth.
Simple erosion prediction models, however, do integrate these functions, and we use such a model to estimate dSL/dCA.
These models however, did not take into account other key agents in the transmission cycle of Lyme disease.
Such models, however, do not provide simple relationships between covariates and the easier interpretable cumulative incidences [ 23].
Other models, however, did show changes in the expression of particular TR isoforms in hypothyroid rats [ 5, 6].
These models, however, did not fit well to the data as none of these models were retained after our selection procedure.
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