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Nevertheless, confronting experimental data with a regulatory network entails many difficulties, such as the incomplete state-of-art of regulatory knowledge, the large-scale of regulatory models, heterogeneity in the available data and the sometimes violated assumption that mRNA expression is correlated to protein activity.
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To model heterogeneity in the populations of defects we assumed a log- normal distribution probability function.
Several approaches have been used in the past to model heterogeneity in bacterial cell populations, with each approach focusing on different source(s) of heterogeneity.
In this work, we have extended the Lubachevsky Stillinger (LS) sphere packing algorithm to create polydisperse packs of non-spherical shapes for modeling heterogeneity in complex energetic materials such as HMX and pressed gun propellants.
Thus, it does not explicitly model heterogeneity in responses.
BSSVS can also generalize to model heterogeneity in aspects of the CTMC process beyond rate variation.
We found no example of its use to model heterogeneity in older individuals' health status.
Our study is also the first to compare multiple weakly and moderately informed approaches to modelling heterogeneity in MTCs.
Random intercept and random slope were taken into account to model heterogeneity in intercepts and in slopes of the individual's own regression line for repeated measurements data.
Results across the replication studies were synthesized using a fixed-effects model; heterogeneity in SNP-retinol associations was assessed using Cochran's Q statistic.
Also, we did not consider random slopes which are commonly used to model heterogeneity in the effect of time on the response variable [ 15].
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