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Previous models have required high Hill coefficients, representing highly cooperative binding of proteins, in order to generate oscillations, although there is no experimental evidence for this.
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Having new transactional models has required big implementation effort to materialize theory into efficient transaction managers.
In comparison, other prediction tools, such as the King's Fund Combined Predictive Model, have required the institution of bespoke computer programmes, with associated costs in terms of software, skills and training.
Inevitably the new marketing model has required clients and agencies to hire engineers and technologists to build the connections, to design the interactions, to calculate the algorithms.
The transition to a tech model has required Ms. Reiniger to confront new challenges, including different growth metrics and software development challenges.
Training of each MLP network for the DOHANN model has required less computer time in comparison to SNN model.
DOI: http://dx.doi.org/10.7554/eLife.00523.022 In order to obtain a set of high confidence calls for each of the models, we have required that the BN calls are confirmed by an independent method called the Causal Inference Test (Millstein et al., 2009) (see details in 'Materials and methods').
Armed with new data, some of S. & P.'s quantitative analysts had produced a new version of the LEVELS model that would have required Wall Street issuers to beef up the "loss-coverage enhancements" in their R.M.B.S.
Consequently, then the total analysis time needed for 6 × 10 6 model evaluations would have required a (theoretical) time of ≈ 41 years.
In the analysis presented here, the estimates for the variance and the mean had been calculated from bins of uniform size rather than from individual conserved segments, as the negative binomial model would properly have required.
Attempts have been made to resolve this issue by modelling, although the complex models developed to date have required more real-world data than are currently available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com