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Furthermore, because nonlinear mixed-effect models have multiple components, it is often unclear which ones should or could be validated for the particular application.
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In contrast, nonparametric population models, having multiple discrete support points which describe the entire model parameter distributions without having to make any assumptions about their shape, can easily compute the expected weighted squared error with which any dosage regimen fails to hit a desired target and can then find the regimen which specifically minimizes that error.
Since the side effects are closely related to the given healthy ranges, the single objective may make the LP model have multiple optimal solutions.
Twenty-four percent of all models and nine percent of complete models contain introns, and only one percent of contigs with at least one gene model have multiple gene models.
Receptor CXCR4 (CD184) plays an important role in the mechanisms of HSCs migration and repopulation, in regard to the observation, that murine fetuses lacking this receptor (CXCR4-null model) have multiple defects that are lethal, including impaired BM hematopoiesis [ 28].
At PMM levels greater than 15, the model has multiple solutions.
In contrast, the Gabszewicz and Wauthy's model has multiple equilibria under the same assumptions.
Each model has multiple start points which are the locations where the trains enter the system.
These increases were, however, unstable and at PMM values greater than 15 the model had multiple solutions.
Unlike [15, 19] in which the system model has multiple zones within the coverage area of an RSU with distinct transmission rates determined by the distances of the nodes from the RSU, our system model has only one zone within the coverage area of an RSU.
As in other cases of coordination failure, Diamond's model has multiple equilibria, and the welfare of one agent is dependent on the decisions of others.
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