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Several experimental models have linked TIMP activity to inflammation, although such a function in breast cancer is unexplored.
Several studies using animal models have linked early exposure to BPA with developmental and reproductive abnormalities in both sexes (Ho et al. 2006; Howdeshell et al. 1999).
Human epidemiological studies, as well as transgenic mouse models, have linked genetic variations in IRAK genes to a collection of diverse diseases including cancer.
Sociocultural models have linked the development of body image disturbance and eating disorders to exposure to media messages promoting the thin female ideal [ 3].
More recent data from animal models have linked infection with HHV-6 and the production of RANTES, the ligand for CCR5, with the acceleration of HIV disease via increased HIV virulence.
Various mouse models have linked bioenergetic status of oocytes to abnormal meiotic outcomes, particularly defects in spindle positioning and chromosome scattering (Wang et al., 2009; Luzzo et al., 2012).
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Now researchers using a mouse model have linked maternal hypoxia during pregnancy plus the presence of only one functioning copy of the Hes7 gene with up to a 10-times-greater risk of congenital scoliosis in offspring compared with the genetic risk factor alone.
A PINK1 knockout mouse model has linked PINK1 with a role in dopamine release and striatal plasticity [16], as well as defects in mitochondrial respiration [17].
To date, no model has linked the population-level dynamics of HIV transmission with a representation of within-host interactions of HIV virus dynamics, host immune response, and drug PK/PD [ 7].
CHEBI identifiers and INCHI codes was added to all metabolites following the MIRIAM standard and the reactions in the model have links to EC-numbers or KEGG reactions.
For example, several miRNA-122 inhibition studies in mammalian model systems have linked the observed decrease in cholesterol and triglycerides in these species to decreased expression of cholesterol and fatty acid synthesis genes [ 9- 11], without establishing a link to direct miRNA-122 target genes.
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