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Agent-based models have extremely wide-ranging properties, yet exhibit characteristic forms of state storage and agent behavior.
As shown in table 2, patients identified by the models have extremely high rates of chronic disease (85 90% with long-term conditions at risk threshold of 50), often with multiple long-term conditions and high Charlson Comorbidity Index levels, indicating serious medical needs.
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The BDC2.5/NOD.scid model has extremely high diabetes incidence, which develops already at 3 4 weeks of age, whereas the NOD.scid does not develop diabetes.
The fixed-effects model had extremely similar performance compared with the mixed-effects model in balanced design, but was slightly less efficient when the number of centres was large (J > 20) in an unbalanced design.
Do any of your model's sections have extremely small or zero diameter?
Nevertheless, animal models have been extremely useful in the evolution of current concepts regarding the etiology of asthma and COPD and genetically engineered mice continue to drive the generation and testing of new hypotheses.
These in vitro cell culture models have been extremely valuable in determining the toxic effects of novel compounds on cellular functions and in studying the mechanisms of barrier formation, the uptake and localization of the compounds within the cell, as well as the effects on cell cell interactions.
Animal models have been extremely helpful to understand the migraine pathophysiology and in developing new therapeutic approaches [19].
Studies using rodent models have been extremely valuable in the understanding of human cerebellar development and the underlying mechanisms of cerebellar malformations.
While existing models of mammary cancer metastases are limited in GEM systems, several models have been extremely informative and have shed important insights into genetic factors that are involved in human metastases.
Although there are differences between the human reproductive system and that of the usual animal models, such models have been extremely useful in assessing risks for key human reproductive and developmental processes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com