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Until now, TTC risk assessment models have excluded proteins because the threshold for exposure to food allergens necessary for sensitization and/or elicitation of a response is in most cases unknown.
However, most models have excluded the PRC and PHC from their discussion of cortical function ([ Squire, 1992; Nadel and Moscovitch, 1997; Winocur et al., 2010; but see Norman and O'Reilly, 2003) and previous studies have not typically included these regions as ROIs (but see Stark and Squire, 2000).
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Relying on a significant genotype tests using a log-additive model would have excluded 57% of the non-replicated and none of the replicated loci, while use of other SNP features and clustering might have missed true associations.
A simpler model than that used here would have excluded some factors and could not determine their contribution to the trial's lack of detectable population-level impact.
In addition, we have excluded the existence of unlinked modifiers in our mouse models by intercross experiments.
In order to attempt to rule the possibility that differences between groups were attributable to the effects of dopamine antagonist medication, we repeated the mixed-model ANOVA having excluded the participants who were taking antipsychotic drugs.
First, unlike DCC where the mouse models have somewhat excluded its role in CRC [ 31] (see the previous section), there have been no further studies on MCC that directly or indirectly suggest or dispute its role in cancer since its alteration in human CRC was first reported [ 38].
However, biochemical evidence for this activity is lacking and alternative models have not been excluded.
In building structural equation models, it is necessary to balance completeness and parsimony; however, if other variables correlated with those included in the model have been excluded, the estimates of those coefficients may be biased.
In general, when between-study heterogeneity is demonstrated or cannot be excluded, random effects models have been accepted as the default across different applications of meta-analysis and this should be accepted also for GWA investigations [1], [2], [5].
Also, the regression model may have particularly excluded some people living alone who had no carer available.
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