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This type of study is impossible in humans due to obvious ethical considerations and the cost and complexity in working with primate models has precluded their use for extensive studies of the exoerythrocytic stage.
The lack of suitable tumor samples from well annotated clinical trials and the resulting reliance on mouse xenograft and in vitro cancer models has precluded the identification of clinically relevant predictive biomarkers for mTOR inhibitors and anti-angiogenic drugs in RCC and other solid tumors [ 39].
Similar(58)
Second, our sample size is relatively small for a twin study and this has precluded the use of quantitative twin model fitting.
The notorious difficulty in obtaining human cardiomyocytes (CMs) and propagating them in culture has precluded their use from many drug screening assays and instigated the use of alternative preclinical models.
Endless warfare has precluded production.
But its eurocentricity has precluded wider use.
Perhaps their incendiary edge has precluded mass appeal.
The judge overseeing the case, John P. Walsh, has precluded any mention of the Chelsea shooting.
– to the Throne of England has precluded him seeing active service.
Stoppard has precluded any chance of our identifying with the character.
These are both very computationally demanding tasks, something that has precluded their wide adoption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com