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Substantia nigra pars reticulata (SNr) is a major basal ganglia output area that is a target of these GABAergic projections, and research from animal models has indicated that stimulation of GABA receptors in SNr can produce motor effects consistent with an antiparkinsonian action.
Although the underlying relationships among systemic diseases and the saliva biomarkers are unclear, our recent study using mouse models has indicated that upon systemic disease development, cancer-specific changes occur in the salivary transcriptomic profiles [38].
Additionally, research in various disease models has indicated the kinase as an interesting inhibitory drug target for various acute or chronic inflammatory diseases.
To date, more and more evidence from animal models has indicated that CIK cells, similar to conventional T cells, can migrate to tumors, tumor-draining lymph nodes, and spleen tissues [ 25, 26].
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Theoretical models have indicated that there are four different classes of pharmacokinetic behavior in tissue, depending on the fundamental steps in distribution.
Recently, cell culture models have indicated that QRFP-26 and QRFP-43 are involved in glucose and fatty acid uptake in pancreatic islets and adipocytes.
Climate and sea ice models have indicated that the region in the high Arctic of Canada and Greenland, where Cornelissen and de Roo were gathering data, will be the last stronghold of summer sea ice as the planet continues to warm.
In addition, models have indicated that the episodic opening and closing of back-arc basins have been the major factors in mountain-building processes, which have influenced the plate-tectonic evolution of the western Pacific for at least the past 500 million years.
Recent studies in animal models have indicated the important role of the recipient׳s immune response in neotissue formation, and that modulating the immune response can reduce the incidence of stenosis.
The resulting smashup would have ejected far more Earth debris into space than other models have indicated, with much hotter temperatures.
Meanwhile, studies using cloud-resolving models in a confined area, such as large eddy simulation (LES) models, have indicated a change in deep convection characteristics at grid spacing less than 1 km (Petch et al. 2002; Bryan et al. 2003).
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