Definitional controversies and limited measurement models have hindered measurement.
Small molecule inhibitors of HCV core protein as antiviral agents have been under intensive development as a viable strategy to eradicate HCV infection, yet lack of a robust and convenient small animal model has hindered the assessment of in vivo efficacy of any antiviral compounds.
However, the absence of DOB design guideline considering plant modelling uncertainty has hindered practical application of the DOB.
However, limited functional annotation in non-model systems has hindered understanding of evolutionary novelties in the insect innate immune system.
Psoriasis is a T-cell-mediated skin disease with autoimmune nature that is generally not observed in animals, this lack of a relevant experimental animal model of psoriasis has hindered the investigation of pathogenesis of disease.
However, the paucity of murine models of ERα+ tumors has hindered studies of the factors that give rise to this prevalent tumor subtype and modulate responsiveness to estrogen-directed therapeutics.
However, the lack of an authentic animal model of Farber disease has hindered this research.
Several recent studies support the AAA′A′BBB′B′ model, but its complexity has hindered genetic and genomic analysis of this important crop.
