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However, the recent introduction of unstructured methodologies and new physical models has greatly enhanced the versatility of CFD.

The advent of genetically engineered mouse models has greatly expanded the scientific tools available to study cellular and molecular mechanisms of cardiac disease.

Empirical testing and verification of the predictions of these theoretical models has greatly lagged the theoretical literature due to a lack of datasets with both information on network structure and socio-economic outcomes of interest.

Study of animal models has greatly advanced our understanding of the genetic mechanisms regulating heart development.

The development of genetically modified, transgenic or knockout, mouse models has greatly advanced our understanding of the molecular basis of initiation, promotion, and progression of breast cancer.

Similar(55)

Collectively, mouse models have greatly enhanced our understanding of physiological p53 function and will continue to provide new biological and clinical insights in future investigations.

Various sophisticated recombinant animal models have greatly aided our understanding of the biology of the VEGFRs.

Although rodent models have greatly contributed to our understanding of human obesity [ 11], experiments using rodent models require considerable staff and infrastructural support, and are relatively expensive.

Mouse models have greatly augmented our understanding of photoreceptor cell fate determination and pathogenesis of retinopathies caused by mutations in transcription factors.

Accordingly, developmental biologists have always been at the forefront of gene expression analysis, and recombinant DNA techniques such as transgenic and knockout models have greatly contributed to elucidation of developmental pathways and networks.

However, although rodent models have greatly contributed to our understanding of human NAFLD, these results have come at a relatively high financial cost because these animals require considerable staff support and specialized infrastructure.

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