Despite Rett occurring predominantly in females, investigations using Mecp2 deficient mouse models have concentrated on males with few exceptions [15,16,20,22].
Several experimental studies in tissue slices and in animal epilepsy models have concentrated on identifying the conditions associated with synchronous and excessive burst firing (Jiruska et al., 2010; Brown and Randall, 2009; Calvin et al., 1968; Jefferys, 1989, 2003).
Past modeling has concentrated on electroluminescent coupling between the cells, although photoluminescent coupling is shown to be important for cells operating near their maximum power point voltage or below or when junction defect recombination is significant.
Research on finite difference techniques for the dispersion model have concentrated on computation accuracy and numerical stability.
Estimating variance components from pedigrees and twin model studies has concentrated on additive variance, to estimate the narrow sense heritability.
The modelling of costs has concentrated on the nominal cost of IVF and IUI.
To date, most mechanistic work using rodent models to examine HAAF has concentrated on the hypothalamus.
In contrast, modeling of malaria vaccines has concentrated on analysing transmission, and in particular identifying the conditions for controlling or interrupting it [7] [11].
The analysis up to this point has concentrated on modeling the representations of individual objects, rather than categorical representations.
Largely because of preclinical work done in the Fmr1 KO mouse model, more recent treatment discovery has concentrated on targeting underlying molecular mechanisms thought to be contributing to the wide range of endophenotypes associated with FXS.
