Sentence examples for models harboring a from inspiring English sources

In agreement with other models harboring a specific ATP synthase deficiency (37– 39), mitochondria from Lrpprc knockout hearts can maintain ΔΨ in the non-phosphorylating state, but are hyperpolarized under phosphorylating conditions (Fig.  5B and C, Supplementary Material, Fig. S3A).

Given the established clinical importance of cyclin D1b induction, novel models harboring a genetic switch from cyclin D1a to cyclin D1b were generated herein and uncovered the effects of the switch to cyclin D1b expression on developmental and cellular transformation phenotypes.

To directly assess the levels of different types of spontaneous mutations in organs and tissues during aging, we have used a mouse model harboring a chromosomally integrated cluster of lacZ-containing plasmids that can be recovered and analyzed in Escherichia coli.

We next took advantage of a previously published rat model harboring a disease-causing point mutation in the gene encoding MKS3 [18], which results in polycystic kidney disease [17] as well as hydrocephalus [9].

While the Apc-Cdkn1a network was generated using tumor-specific ApcMin/+ data – a model harboring a number of background genetic lesions [41] – the intestinal tissue obtained from the Apc1638N+/− and Cdkn1a−/− mice at 3 months of age is relatively polyp free, thus allowing us to gauge the effect of a single genetic perturbation on the pre-neoplastic epithelium.

Moreover, young mouse model harboring a mutation favoring generation of Aβ 1-42 over Aβ 1-40 had a low Aβ 40/42 ratio, was shifted to plaque deposition [ 45].

Other studies have examined the expression of the C9orf72 gene using a transgenic mouse model harboring a targeted LacZ insertion [ 32].

Given the importance of 1p36 deletion CNVs in humans, we decided to study a chromosome-engineered mouse model harboring a 4.3 Mb deletion in 4E2 [ 19].

For example, an elegant study using a mouse model harboring a transcription-dead p53 mutant, p53 (25,26,53,54), showed that the transcriptional activity of p53 is absolutely required for its tumor suppressive function [ 76].

Experiments by Cheng and colleagues using a mouse model harboring a TR β mutant (TR βPV/PV) revealed that accumulated PTTG1 physically interacts with the DNA-binding domain of TR β1 through the N-terminal region.

This was recently shown to result in lymphoid hyperplasia in a mouse model harboring a tyrosine 641 mutation, but in isolation from other oncogenic events, this was insufficient to drive overt lymphoma.