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In addition, mouse models generated thus far have failed to adequately replicate the abnormal gene expression, developmental abnormalities, protein hypoglycosylation and loss of lipid-linked oligosaccharides (LLOs; the sugar donor for glycosylation events) that are associated with the human disease.
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Two Pdzk1−/− models have been generated thus far, however one is on a pure 129SvEv genetic background (Pdzk1 tm1Kr) [27], and a second has a mixed B6:129 background (Pdzk1tm1Dls) [44].
Consequently, domain experts, despite not having formal software engineering training, find themselves creating models (designs) from which code is generated, thus effectively contributing to the design and coding activities of software development.
Till date, there are no known inhibitors of iPGM and the homology model generated can thus be utilised to design a series of inhibitors providing us with possible antifilarial drugs.
Thus, the models generated on the training set using 26 aminooxadiazoles were used to predict the PIM1 inhibitory activity of the remaining molecules.
Thus, over-complex models generate wide ranges of possible results, with no guidance as to those which are the more probable.
This suggests that localities in each cluster contain unique bioclimatic niche information and thus a model generated using data from only a single cluster does a poor job of predicting the detailed geographic distributions of parasitoids in the other clusters, even though, at least qualitatively, the K1-only ENM does a fairly good job of reproducing the distribution map from the full ENM.
Thus, the 3D QSAR model generated can be used for fishing out novel natural compounds with inhibitory activity against mPTPB.
The PASE model generated in this study lacks primitive endoderm and trophoblast, and thus cannot form yolk sac and placenta.
Neither model generated mass followings.
The models thus generated were refined with PHENIX using individual B-factor refinement (occupancies were not refined).
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