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These aspects have been only partially elucidated using the Fig4-null mouse models generated so far.
The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so far.
Mouse models generated so far provided a great deal of important data (Table 1), but as illustrated by the Li–Fraumeni reconstruction attempts, possess limitations in simulating the phenotypic effects of human TP53 mutations.
19 20 As demonstrated from the human cardiac disease models generated so far, several drugs have been tested on patient-specific iPSC-CMs and found either to ameliorate or alleviate the disease phenotype.
This raised the question whether this and other animal models generated so far (for example, MLL-AF9 model, see Stubbs et al.; TEL-AML1 model, see Ford et al.; TEL-AML1 model, see Schindler et al).
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The BEIR VII model generates so-called lifetime attributable risk (LAR) factors, which estimate the likelihood of cancer in hypothetical individuals as a function of dose.
Second, multivariate unconditional logistic regression models were generated, so that we could determine which of the variables covered was independently associated with suffering migraine in our population.
For each of these SMILES, 3D conformational models were generated, so that each compound is represented as a set of low-energy conformations.
Logistic regression models were generated so that, using self-rated health "poorer" and "better" response groups as the dichotomous dependent variable, we could ascertain which demographic and health-related variable(s) were independently associated.
Given that gene expression results indicated some models undergo profound changes with in vivo passage, a general metric of stability was generated so models could be ranked accordingly.
The emitting of gamma rays was not predicted in pre-collision models, which is why it's generated so much excitement, but also why there's currently no explanation for what the origin could be.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com