CoMFA and CoMSIA models give reliable correlative and predictive abilities but the CoMFA model performance was slightly better than CoMSIA.
The model gives reliable results both for the species distribution and the vapor liquid equilibrium of the studied mixtures.
Through comparisons of predictions with measurements for four types of wheel and one track type, it is shown that the TWINS model gives reliable predictions.
It is also shown that the model gives reliable extrapolations to low energies where experimental data on the cumulative number of levels can be extracted.
This comparison indicates that it is possible to separate the part of the chemspace, in which the model gives reliable predictions, from the part consisting of structures too dissimilar to the training set to apply the model successfully.
We showed that the model gives reliable predictions of growth, nutrient utilization (including amino acid retention), and body composition over a timespan of several months, longer than most of the previously developed predictive models.
Both CoMFA and CoMSIA analysis gave reliable models with q2 values >0.50 and r2 values >0.92.
This computational study gave reliable structural models for D2, 5-HT2A, and 5-HT7, whadh had overall structural complementarities with a salt bridge anchor at the center of the lurasidone molecule, but not for H1 and M1 owing to steric hindrance between the norbornane-2,3-dicarboximide and/or cyclohexane part of lurasidone and both receptors.
However, when the change of electrode polarity has been considered, very few models have given reliable predictions.
Hence, for this particular case, the lumped plasticity model presented, that can be simply applicable in the daily design practice, gave reliable results.
