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The final Cox models fulfilled the proportional hazards assumption.
The models fulfilled the Cox regression model assumptions (linearity of continuous variables, proportional hazards assumption and lack of interaction) unless otherwise specified.
All analysed FE models fulfilled the claimed 1% convergence criterion on tensile stress maxima applied to the meniscal component after a single mesh refinement step.
All models fulfilled the rule that at least 10 observations (i.e. patients) per included covariate have to be available for the regression to avoid overestimated and underestimated variances [ 42].
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In vivo virulence of these factors has been established in animal models fulfilling the paradigm of "Molecular Koch's postulates".
To this end, as described above, we identified a non-empty set of logical models fulfilling the experimental constraints and exhibiting bistability.
Having used the Johnson Transformation, the model fulfilled the criteria of the Anderson Darling test (p = 0.303).
Therefore, the model fulfilled the criteria of being capable of reproducing real physiological phenomena, like the [Ca2+]i-frequency curve, and could robustly simulate the caffeine pulse experiment.
This model fulfilled the assumptions of linearity, normality, constant variance, independence and collinearity (Table 5).> -wrap-foot> R: 0.433; normality: p = 0.332.
In defense of this, however, we restricted our analyses to only include meaningful variables that were chosen a priori and our multivariate modeling fulfilled the requirement (1 variable for 10 outcome events) for having reliable parameter estimates.
Although simultaneous parameter fitting and full parameter identifiability could not be accomplished in this context, the updated model fulfilled the Agoram 25 criteria: (i) Fit for purpose: only compartments and parameters that were necessary to improve predictions of specific measurable clinical endpoints were added to the model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com