However, comparison of receptor homology models for wild-type pentamers suggests that salt bridges in the intracellular domain of the homomer may impart structural rigidity, and we hypothesized that this rigidity could account for the low conductance.
Moreover, the predictive variables were different for the taxa, with the regression model for wild bees including both patch and matrix variables, that for plants richness including patch variables only, and that for ants including matrix variables only.
We have modified the existing kinetic model of the EGFR signaling pathway and built new models for H1299 wild type (H1299WT), H1299 with overexpressed wild type EGFR H1299EGFR-WTT), and H1299 overexpressing the EGFR with L858R mutation (H1299L858R).
A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack.
(R. chinensis 'mutabilis') as model for wild-type Chinese roses.
The elevated values of δNH (>0.2 ppm) are mapped on the model for wild-type cTIM shown in Figure 2C.
Analyses of kinetic and equilibrium data for both oxygen and CO within the framework of the MWC allosteric model for wild-type HbI and its mutants provide remarkably good agreement for binding both ligands, strongly suggesting a very similar cooperative mechanism is operative for CO and O2.
The X-ray structures used as models for the wild type and T766M mutant sTKD dimer are deposited under the Protein Data Bank (PDB) codes 5CNO (ref. 6) and 4I24 (ref. 72), respectively.
The models for both, wild type and mutant, include six metabolites, namely: glucose, fructose, sucrose, sugar phosphates, and starch, as well as a combined sink export, which are interconverted through seven reactions.
Like in the previous section, the performance of the methods to accurately simulate the dynamics of the metabolite concentrations and fluxes is determined based on the RSS values between the results of the constrained-based approaches and the kinetic models for the wild type plant and the inv4 mutant (proposed in [ 9]).
