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These programs have become models for TB treatment around the world.
The reader can refer to more related mathematical models for TB; see [5 7].
In common animal models for TB such as mice and guinea pigs, H37Ra does establish an infection, and does multiply within these hosts [4], [5], [6].
Here we provide a comprehensive histopathological and microscopic evaluation to elucidate the location of bacterial populations in animal models for TB drug development.
Surprisingly, there is limited to no information on the location of M. tuberculosis in the most widely used animal models for TB drug development.
This finding has been previously reported in CART models for TB in hospitalized patients [ 8].
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We specified a compartmental model for TB [13] and developed the model to explicitly incorporate age structure.
A diagnostic model for TB with high sensitivity and specificity was developed using mass spectrometry combined with magnetic beads.
It is another useful mouse model for TB research because the genetic diversity in the DO population mimics the diversity in the human population.
Survival analyses included Kaplan-Meier curves and Cox proportional hazards model for TB and non-TB related deaths usinon-TB relatede time the periodeathssed from diagnosis.
Silva and Torres [9] proposed a population model for TB-HIV/AIDS coinfection transmission dynamics, they applied optimal control theory to TB-HIV/AIDS model to study optimal strategies for the minimization of the number of individuals with TB and AIDS.
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