In light of these results, one model for suppression is that the suppressors strengthen the cell envelope such that loss of σE activity and the resultant impact on the cell envelope are no longer lethal.
Oenothera is a classical model for suppression of HR in PTH species.
The paper presents a new model for suppression of protrusion formation, and postulates a role for the membrane curvature seen in the filopodial birthplaces.
In the simulation study we have generated small-study effects by inducing PB using different models for study suppression.
This suggests a model for the suppression of axr3-1 and axr3-3 phenotypes by pax1-1.
Based on these results, Dr. Pandolfi proposed a "continuum model for tumor suppression," which reflects PTEN activity levels rather than stepwise changes in copy number.
Consistent with these data, one potential model for the suppression is that Esa1 acetylation of Nab3 influences its function such that the reduced Nab3 acetylation in esa1 mutants results in its reduced cell viability and defects in rDNA silencing.
Most reported miRNA targetome analyses in the context of virus infection have been performed in latently infected cells and lack reliable models for quantifying the suppression efficacy at specific miRNA target sites.
Tau expression in this model is regulatable, allowing for suppression of mutant tau expression until adulthood and prevention of possible developmental alterations resulting from P301L tau expression during development.
Based on PK/PD model fitting, QGE031 demonstrated a ninefold increase in potency for suppression of free IgE compared with omalizumab.
